Background and Purpose: Pain perception with arteriovenous fistula (AVF) cannulation is a major concern among patients undergoing
hemodialysis. This study aimed to compare the efficacy of cryotherapy and placebo in the reduction of AVF puncture-related pain in
hemodialysis patients.
Methods: This randomized clinical trial was conducted on 50 patients undergoing hemodialysis selected via random sampling. Patients
were randomly divided into two groups of intervention and control. Patients in the intervention group received cryotherapy using
ice cubes wrapped in latex gloves, which were placed on the back of the hands without AVF (between the index finger and thumb).
The same process was performed on the patients of the control group by using wooden cubes as placebo instead of ice cubes. Pain
perception of the patients was recorded during two consecutive hemodialysis sessions using a visual analogue scale. Data analysis was
performed in SPSS V.13 using Chi-square and independent T-test.
Results: With cryotherapy, scores of AVF puncture-related pain significantly reduced from 5.9±0.96 in session one (routine care) to
3.2±1.71 in session two of hemodialysis. However, no significant difference was observed between the two sessions in patients of the
control group (P=0.07).
Conclusion: According to the results of this study, cryotherapy, as a non-pharmacological and complementary approach, could be
effective in the prevention of the pain associated with AVF cannulation. Therefore, it is recommended that nurses apply this method
before AVF cannulation in order to alleviate pain intensity in hemodialysis patients.