Background and Purpose: Despite extensive research on family planning and education, reproductive behavior of high-risk couples
for thalassemia remains a major concern among medical professionals. This study aimed to evaluate the knowledge and attitude of
carrier couples for transfusion-dependent thalassemia major (TDTM).
Methods: This case-control study was conducted 327 carrier couples for thalassemia minor. Contact information of the couples
was obtained from three healthcare centers randomly selected from the eastern, central and western parts of Mazandaran province,
Iran. To match the socioeconomic status, two control families (right and left neighbors) were interviewed per each carrier couple.
Epidemiological characteristics and knowledge of the carrier couples were assessed via 10 and 20 questions, respectively, and scores
above 15 were interpreted as adequate knowledge. Moreover, attitude of the subjects was evaluated via 16 items scored based on a
four-point Likert scale. Data analysis was performed in SPSS V.16 using Mann-Whitney U test and T-test for the comparison of study
groups, and P value of less than 0.05 was considered significant.
Results: In total, 327 high-risk couples for minor thalassemia and 660 control families were enrolled in this study. Among the subjects,
32.6% and 22.3% had adequate knowledge about thalassemia. In addition, attitude of the carrier couples was positive in 58% and 41%
of the cases. Also, 30.5% and 31.2% of case and control subjects had favorable socioeconomic status, respectively.
Conclusion: According to the results of this study, knowledge of carrier couples was adequate with regard to TDTM, and they had
a positive attitude toward receiving prenatal diagnosis for this syndrome. However, reproductive practice of high-risk couples was
relatively poor. Therefore, it is recommended that reproductive behavior of high-risk couples for TDTM be monitored regularly in
order to improve their practice.